ImmuKnow® as an immune monitoring tool following organ transplantation ImmuKnow® : biomarqueur de l’immunité cellulaire après transplantation d’organe

R é s u m é » ImmuKnow® is a non-invasive biomarker of patient cellular immune status. It helps identify transplant patients at risk of overor under-immunosuppression after transplantation. ImmuKnow® detects intracellular ATP synthesis in stimulated CD4+ cells from whole blood. The amount of ATP produced refl ects global T cell function of patients exposed to a combination of immunosuppressive drugs. The ImmuKnow® assay defi nes three immunological response zones: strong, moderate and weak. These zones can guide physicians in patient management. The assay can be used in a variety of applications, including transplantation, management of infectious diseases, autoimmunity, cancer, as well as vaccine and drug development.